Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.
Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.

Administration

How to Prepare Thymoglobulin® for Administration1

How to prepare Thymoglobulin for Administration step by step chart

  • Recommended volume: 50 mL of infusion solution per vial of Thymoglobulin (total volume usually between 50 to 500 mL)1

Thymoglobulin Administration

  • Thymoglobulin should be administered under strict medical supervision in a hospital setting and patients should be carefully monitored during the infusion1
  • Thymoglobulin is administered by intravenous injection and infused through a 0.22-μm filter into a high-flow vein (follow the manufacturer's instructions for the infusion administration set)1
  • Set the flow rate to deliver the dose over a minimum of 6 hours for the first dose and over at least 4 hours for subsequent doses1
  • Thymoglobulin is less likely to produce side effects when administered at the recommended flow rate1

Rapid infusion rates have been reported with cases consistent with cytokine release syndrome (CRS). Severe IARs are consistent with CRS, which is attributed to the release of cytokines by activated monocytes and lymphocytes. Severe acute CRS can cause serious cardiorespiratory events and/or death.1

Close compliance with the recommended dosage and infusion time may reduce the incidence and severity of IARs. Slowing the infusion rate may minimize many of these IARs.1

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About Thymoglobulin Dosing.
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See Preinfusion Considerations
and Storage Information.
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Important Safety Information for Thymoglobulin
[Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Important Safety Information for Thymoglobulin [Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Click here for full Prescribing Information including Boxed WARNING.

Reference:
  1. Thymoglobulin [prescribing information]. Cambridge, MA: Genzyme Corporation; 2017.