Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.
Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.

Dosing

The Right Dose of Thymoglobulin® Offers Clinically Demonstrated Protection for Your Patient's New Kidney

Appropriate dosing for Thymoglobulin is different from dosing for other anti-thymocyte globulin (ATG) products, as protein composition and concentrations vary depending on the source of ATG used. Physicians should therefore exercise care to ensure that the dose prescribed is appropriate for the ATG product being administered.1

Recommended dosing for Thymoglobulin1
Recommended dosing schedules for Thymoglobulin chart
  • Thymoglobulin is used with concomitant immunosuppression. To prevent over-immunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of Thymoglobulin use1
  • Thymoglobulin overdosage may result in leukopenia (including lymphopenia and neutropenia and/or thrombocytopenia, which can be managed with dose reductions1
The indicated dose of Thymoglobulin is 1.5mg/kg of body weight administered daily for 4 to 7 days

Dosing Adjustments and Considerations

The immunodeficiency that results from immunosuppression predisposes patients to disorders of immune surveillance and response, including infection and malignancy. The increased risk of infection and malignancy are related more to the overall intensity of immunosuppression than to any specific agent.2,3

  • To prevent over-immunosuppression, physicans may wish to decrease the dose of maintenance immunosuppression regimen during the period of Thymoglobulin use1

During Thymoglobulin therapy, monitoring total lymphocyte count or T-cell subsets, such as CD2 and CD3, may help assess the degree of T-cell depletion.1

  • WBC and platelet counts should be monitored during and after therapy to assess the degree of neutropenia and thrombocytopenia, respectively1
If WBC or platelet counts fall within the parameters shown in the table below, dosage adjustments may be appropriate.1
Recommended dose adjustments for Thymoglobulin chart

See How to Administer
Thymoglobulin.
Learn More


See Preinfusion Considerations
and Storage Information.
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Important Safety Information for Thymoglobulin
[Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Important Safety Information for Thymoglobulin [Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Click here for full Prescribing Information including Boxed WARNING.

References:
  1. Thymoglobulin [prescribing information]. Cambridge, MA: Genzyme Corporation; 2017.
  2. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004;351(26):2715-2729.
  3. Kahan BD. Individuality: the barrier to optimal immunosuppression. Nat Rev Immunol. 2003;3(10):831-838.