Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.
Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.

Dosing

The Right Dose of Thymoglobulin® Offers Clinically Demonstrated Protection for Your Patient's New Kidney

Appropriate dosing for Thymoglobulin is different from dosing for other anti-thymocyte globulin (ATG) products, as protein composition and concentrations vary depending on the source of ATG used. Physicians should therefore exercise care to ensure that the dose prescribed is appropriate for the ATG product being administered.1

Chart with recommended dosing schedules for Thymoglobulin for both prophylaxis and treatment of acute kidney rejection


  • Thymoglobulin is used with concomitant immunosuppression. To prevent overimmunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of Thymoglobulin use1
  • Thymoglobulin overdosage may result in leukopenia, including lymphopenia and neutropenia and/or thrombocytopenia, which can be managed with dose reductions1
The indicated dose of Thymoglobulin is 1.5mg/kg of body weight administered daily for 4 to 7 days image

Dosing Adjustments and Considerations

The immunodeficiency that results from immunosuppression predisposes patients to disorders of immune surveillance and response, including infection and malignancy. The increased risk of infection and malignancy are related more to the overall intensity of immunosuppression than to any specific agent.2,3

  • To prevent overimmunosuppression, physicians may wish to decrease the dose of maintenance immunosuppression regimen during the period of Thymoglobulin use1

During Thymoglobulin therapy, monitoring total lymphocyte count may help assess the degree of T-cell depletion.1

  • WBC and platelet counts should be monitored during and after therapy to assess the degree of neutropenia and thrombocytopenia, respectively1
Tailoring Thymoglobulin Dose Can Help Manage Your Patient’s Overall Immunosuppression1
In all appropriate patients, the Thymoglobulin dose should be reduced to prevent overimmunosuppression1,*

Recommended dose adjustments for Thymoglobulin chart
  • Low counts of WBCs and platelets are reversible following dose adjustments1


*Monitor for adverse reactions and total WBC and platelet counts to help identify appropriate patients.1
See How to Administer
Thymoglobulin.
Learn More


See Preinfusion Considerations
and Storage Information.
Learn More

Important Safety Information

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Important Safety Information

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Click here for full Prescribing Information including Boxed WARNING.

Abbreviations: WBC, white blood cell.

References:
  1. Thymoglobulin [prescribing information]. Cambridge, MA: Genzyme Corporation; 2020.
  2. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004;351(26):2715-2729.
  3. Kahan BD. Individuality: the barrier to optimal immunosuppression. Nat Rev Immunol. 2003;3(10):831-838.