Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.
Indication: Thymoglobulin® (anti-thymocyte globulin (rabbit)) is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Thymoglobulin is to be used in conjunction with concomitant immunosuppression.

Preinfusion & Storage

Storage & Handling

Thymoglobulin® is supplied for injection as single-use 10-mL vials with 25 mg of rabbit anti-thymocyte globulin (ATG) sterile lyophilized powder intended for reconstitution prior to intravenous administration.1

  • Store in refrigerator at 2°C to 8°C (36°F to 46°F)1
  • Protect from light1
  • Do not freeze1
  • Do not use after the expiration date indicated on the label1

Thymoglobulin is stable after reconstitution.1

  • Reconstituted Thymoglobulin is physically and chemically stable for up to 24 hours at room temperature1
  • Room-temperature storage of Thymoglobulin is not recommended1
  • Reconstituted product contains no preservatives and should be used immediately1
  • Discard any unused drug remaining after infusion1

Certain Medications Should Be Given Prior to Thymoglobulin Infusion

  • Thymoglobulin is routinely used in combination with other immunosuppressive agents. Infections (bacterial, fungal, viral, and protozoal), reactivation of infection (particularly CMV), and sepsis have been reported after Thymoglobulin administration in combination with multiple immunosuppressive agents. These infections can be fatal1
  • Prophylactic antifungal and antibacterial therapy is recommended if clinically indicated1
  • Antiviral prophylactic therapy is recommended for patients who are seropositive for CMV at the time of transplant and for CMV-seronegative patients scheduled to receive a kidney from a CMV-seropositive donor1

Premedication with corticosteroids, acetaminophen, and/or antihistamine 1 hour prior to each infusion of Thymoglobulin is recommended and may reduce the incidence and intensity ofinfusion-associated reactions (IARs)1

Reactions at the infusion site can occur and may include pain, swelling, and redness of the skin. IARs may occur as soon as the first or second infusion during a single course of Thymoglobulin treatment.1

Educate Your Patients About Treatment With Thymoglobulin

Advise patients receiving Thymoglobulin that they will be monitored by a physician experienced in immunosuppressive therapy for the management of kidney transplant patients.1

  • Infusion-associated reactions
    Advise patients of the signs and symptoms of IARs (flu-like symptoms; eg, fever, chills, nausea, muscle or joint pain) and the need to take premedications as prescribed.1 Refer to recommendations in the prescribing information to help reduce IARs1
  • Allergic reactions
    Determine if the patient has known allergies to rabbits or rabbit proteins. Determine if the patient has had significant exposure to rabbits1
  • Infections
    Inform patients of the increased risk of infection while taking immunosuppressive therapy. Instruct patients to immediately report signs or symptoms of infection and to take prophylactic anti-infectives as prescribed1
  • Malignancies
    Inform patients of the increased risk of malignancies while taking immunosuppressive therapy, especially skin cancer. Instruct patients to limit exposure to sunlight and UV light by wearing protective clothing and using sunscreen with a high protection factor1
  • Immunizations
    Advise patients that they should not receive immunizations with live viral vaccines if they have recently been treated with Thymoglobulin1
Get More Information
About Thymoglobulin Dosing.
Learn More


See How to
Administer Thymoglobulin.
Learn More

Important Safety Information for Thymoglobulin
[Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Important Safety Information for Thymoglobulin [Anti-thymocyte Globulin (Rabbit)]:

WARNING: IMMUNOSUPPRESSION. Thymoglobulin should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Click here for full Prescribing Information including Boxed WARNING.

Reference:
  1. Thymoglobulin [prescribing information]. Cambridge, MA: Genzyme Corporation; 2017.